The Study of Olanzapine Combines Exercise on Metabolic Disturbances in C57BL/6JNarl Mice
| Autor: | I- Shuan Chao, 趙逸璇 |
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| Rok vydání: | 2011 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 99 Olanzapine (olz) is a second generation antipsychotic drug which works on serotonin receptors and dopamine receptors in the brain. Olz is greatly used because it possess advantages over old agents (first generation antipsychotics) in terms of reduced adverse effects like extrapyramidal symptoms. However, olanzapine also induces a marked side effect including weight gain, raising blood glucose level and reducing insulin sensitivity. These have been indicated to be associated with metabolic syndrome. On the other hand, exercise is known for its benefits in weight management. It also lowers blood glucose and improves insulin sensitivity. C57BL/6JNarl female mice have been selected in this study to investigate the metabolic disturbance that induced by olz. Moreover, whether exercise may compensate the side-effect that induces by olz was also studied here. Our results show that olz can induce an significantly increase in weight gain, food intake, accumulation of visceral and subcutaneous adipose tissue, blood glucose level, serum insulin level, serum leptin and liver triglyceride in model mice. Exercise is observed to be effective in reducing the effects of olz on blood glucose, serum insulin and improve HOMA-IR. Exercise also reduces accumulation of adipose tissue, but fails in lowering serum leptin and liver triglyceride. The expression of hormone sensitive lipase (HSL) is lower in visceral fat of mice treated by olz. We also observed that mice given olanzapine led to reduce their body temperature but increase in HSL expression in brown adipose tissue. Our data suggests that C57BL/6JNarl mice treated with olz reduces energy expenditure and increases food intake which similar to the effects of leptin resistance and the combination of exercise seems to be helpful in the glucose metabolism but show no effects in the lipid metabolism. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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