α-Amidation of Oligopeptide through Organic Synthesis Approach
| Autor: | Shi-Hong Chen, 陳仕泓 |
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| Rok vydání: | 2011 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 99 This study is to develop methods to produce peptides with α-amidation, which are observed in many neuropeptides and endocrine hormones, through organic synthesis. There are two approaches designed to achieve this purpose. First one is to replace the carboxylic acid of the last residue in the target peptide with the amide functional group. The other one is to conjugate the peptide without the last residue to the α-amidated amino acid as the last residue in the peptide sequence to produce the target peptide. The syntheses are intended to increase the production and to reduce the cost at the same time. In this study, Mastoparan B was chosen as potential target, and we performed a series of simulation synthesis research. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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