Return to ordinary diet has a better inhibition than low dose of Ginkgo biloba extract on the progression ofnon-alcoholic steatohepatitis in rat
| Autor: | Yung-Fa Chen, 陳永發 |
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| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 98 The prevalence of non-alcoholic fatty liver disease (NAFLD) is about 10~24% in the West. Approximately 2~3% of the presentations about this disease were chronic hepatitis and eventually liver cirrhosis or hepatocellular carcinoma may develop. Because lack of specific efficacy of drugs except weight loss, exercise and improvement of insulin resistance, non-alcoholic steatohepatitis (NASH) will surely become an important issue in the future. Strong free radical scavenging ability and antioxidant capacity of Ginkgo biloba extract（EGb 761）has been found in recent years, so the purpose of this study is to observe whether the EGb 761 has the preventive effect on the progression of NASH. NASH confirmed by liver pathology after liquid high-fat diet feeding 16 weeks, these male Wistar rats were randomly divided and fed as following 3 groups for more 6 weeks : liquid high-fat diet group (H group), liquid high-fat diet plus EGb 761 group ( HG group) and ordinary solid diet group (N group). EGb761 was delivered by intra-peritoneal injection with the daily dose of 25 mg/ kg of body weight. Only serum triglyceride and glucose significantly decreased in HG group compared with H group in blood biochemistry（P |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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