Development and Biocompatibility Tests of A Novel Paramagnetic Nano-membrane
| Autor: | Ya-Hui Chan, 詹雅惠 |
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| Rok vydání: | 2010 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 98 In the treatment of extensively burned patients, grafting of devitalized tissue is the major source of skin replacement. However, patients with large surface area burns cannot be completely grafted. Artificial skin replacement and wound dressing offer effective treatment for burn and wound care in the treatment of patients with large surface area burns. Accordingly, development of a functional and cheap artificial dressing has become an urgent goal for emergency medicine. Many researches have proved that magnetic stimulation can promote wound healing. However, artificial dressing combined with static magnetic field is still unavailable. With this regard, the aim of this study is to develop a novel magnetic dressing material. The Fe3O4 nano-particles were prepared by the chemical-precipitation method, and the diameter of there particles were analyzed using transmission electron microscopy. After mixing the Fe3O4 nano-particles and poly-lactic acid (PLLA) solution with a concentration of 3g/3g (Fe3O4/PLLA), membrane with nanofiber was manufactured via electrospinning technique. Our results showed that the diameter of the Fe3O4 nanoparticles concentrated at 2-8 nm (84.2%). After magnetizing the new-developed PLLA- Fe3O4 membrane, we found the residual magnetic intensity was 0.28±0.06 G, and there exists an approximate linear relationship between the magnetic intensity and membrane thickness (R= 0.82, p |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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