Investigation of possible mechanisms in light activation of light-responsive elements within genes
| Autor: | Zi-Peng Zhao, 趙子鵬 |
|---|---|
| Rok vydání: | 2010 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 98 A gene expression is generally believed to be singled out from within the large chromosome pool once its corresponding promoter is activated by some means. It is suspected that light interference may play an essential role in pulling this trigger. In fact, all known light-responsive promoters thus far are concluded, within our lab, to be activated in a more-or-less unintended statistical sampling fashion, rather than in a deterministic precise manner. It is thus argued that the known population distribution of base pairs A, T, G, C, within a specific promoter can always be matched by the so-called activation probability distribution deduced from a weight-summed light absorption tendencies of each DNA base pair on photons generated by interference of UV, VIS, and IR lights within a nonlinear bio-system. In other words, such statistical means of promoter sampling/triggering does not guarantee the offering of correct promoter sequence ordering each time. Nonetheless, owing to the typically small number of base pairs (of about 6-10) within a promoter, in principle it does not take long to reach the eventual matching ordering after several trials. Subsequently, the corresponding mRNA is transcribed and then the specific protein generated. Examples demonstrating such gene expression scheme are provided, even though the underlying physical processes connecting light absorption and promoter activation remain largely unknown. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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