Heart Rate Variability during Therapeutic Hypothermia and Post-resuscitation Outcomes in Animals Subjected to Experimental Cardiac Arrest
| Autor: | Shih-Heng Chang, 張適恆 |
|---|---|
| Rok vydání: | 2010 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 98 Background: Little is known regarding heart rate variability (HRV) during therapeutic hypothermia (TH) in the post-resuscitation setting, as well as the role of HRV in predicting post-resuscitation outcome. Objective: This study was aimed at testing the association between HRV and TH, and investigating the ability of HRV in predicting outcome in the post-resuscitation setting. Materials and methods: Adult male Wistar rats were subjected to asphyxial cardiac arrest (CA) and subsequent cardiopulmonary resuscitation (CPR). Once return of spontaneous circulation (ROSC) was achieved, TH was implemented using external cooling method and lasted at target temperature (32 to 32.5℃) for 4 hours. Electrocardiographic (ECG) signals were recorded throughout the experiment, and HRV was calculated using 5-min epochs hourly. Survival was assessed after 3 days. Thereafter, the association between HRV and 3-day survival was evaluated. Results: HRV, in terms of various time-domain and power spectral measures, was elevated during TH when CA was not induced. When compared with sham group, rats that were subjected to CA had higher HRV in the post-resuscitation period. HRV was even higher when TH was induced in the post-resuscitation period. When evaluating the association between HRV and 3-day survival, HRV during normothermia demonstrated higher associations with outcome, compared with HRV during TH. Conclusion: HRV reflected the autonomic modulation in response to TH and induced CA and elevated during these stresses. The predictive value of HRV on 3-day survival was better during normothermia than during TH. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
| Externí odkaz: |
|