The effect of carbohydrate and exercise on postprandial lipid metabolism related gene expression
| Autor: | Tseng Mei-Hui, 曾玫蕙 |
|---|---|
| Rok vydání: | 2010 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 98 Postprandial hyperlipemia increases the risk of cardiovascular diseases. Strategies to reduce postprandial lipemia might lower the risk of cardiovascular diseases. The purpose of this study was to investigate the effect of carbohydrate and exercise on lipid metabolism related gene expression after high fat meal. Eight healthy, active male subjects completed 4 experimental trials in a randomized order and cross-over design. After overnight fast, subjects either ingested 75 g fructose (F) or 75 g glucose (G) and rest or exercise at 60% VO2max for 1 hour (F+EX, G+EX) before an oral fat tolerance test. Blood samples were collected during 6 hour postprandial period. The results showed that F and F+EX induced higher plasma ApoA-I and lower plasma total cholesterol and LDL-C than G and G+EX. There were no significantly differences in ApoA-I、Apo B、LDLR、HMGCR、VLDLR gene expression between trials. However, there was a trend that ingesting fructose group indicated a lower VLDLR gene expression. The current data suggested that ingestion of different carbohydrates and exercise before a high fat challenge did not influence postprandial lipid metabolism related gene expression. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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