Joined Use of Oxazolidinone and Desymmetric Amino Protection in Application of Oligosaccharide Synthesis
| Autor: | Lin, Shih-Che, 林士哲 |
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| Rok vydání: | 2010 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 98 Joined use of N-benzyl oxazolidinone and N-benzyl-N-benzyloxycarbonyl (N-BnCbz) desymmetric amino-protecting function is reported. The new synthetic approach enables the facile preparation of type 1 and type 2 LacNAc disaccharide in satisfactory yield. One-pot deprotection of N-BnCbz and O-benzyl ether is achieved by hydrogenolysis under mild conditions. Further application of this protection strategy realizes the synthesis of trisaccharide H blood group substrate. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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