The Effect of Stratum Corneum Hydration on Transdermal Drug Delivery Process
| Autor: | Chun-Yuan Shin, 施淳元 |
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| Rok vydání: | 2010 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 98 Water not only serves as a solvent, but also is a chemical penetration enhancer in transdermal drug delivery system. Therefore, the hydration of skin is an important topic. In the study, we aim at obtaining a series of effective permeability coefficients of drugs, with a range of lipophilicity along with the corresponding drug release curves, which provide an important approach for the investigation of the effect of hydration on transdermal drug delivery. The main purpose of this study is to use a simple and accurate numerical model to fit the effective permeability coefficient for various drugs. as the precise quantification of effective permeability is obtained, attempts are made to elucidate the mechanism for the hydration of skin impacting the effective permeability of skin. And drugs of various lipophilicity(termed Ko/w) are investigated to study the correlation between lipophilicity of drug molecules and the hydration of the stratum corneum layer. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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