Assessment of metastasis related genes as tumor markers of oral squamous cell carcinoma
| Autor: | Yu-Shan Cheng, 鄭宇珊 |
|---|---|
| Rok vydání: | 2010 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 98 Oral cancer has been included among the top ten causes of death among cancer. However, it still challenged to find out more tumor markers in oral squamous cell carcinoma (OSCC). We performed protein interaction analysis for some candidate genes related to cell metastasis and extracelluar matrix (ECM) pathway by using bioinformatics tools to mine on our previous microarray data. Candidate genes including matrix metalloproteinase-2 (MMP2), matrix metalloproteinase-9 (MMP9), TIMP metallopeptidase inhibitor 1 (TIMP1), met proto-oncogene (MET), syndecan 4 (SDC4) and laminin alpha 4 (LAMA4). To validate the performance for detection OSCC, we had collected 53 paired OSCC and margin controls for real-time PCR analysis. Currently, gene expression of these candidates in OSCC are compare with that of in control for MMP2 (51.71±2.37 vs. 51.02±1.78; p=0.048; paired-samples t-test), MMP9 (48.85±3.17 vs. 43.90±5.77, p |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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