Noninferiority test based on restricted mean lifetime
| Autor: | Ya-shan Cheng, 鄭雅珊 |
|---|---|
| Rok vydání: | 2009 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 97 The noninferiority test is required for approving a new drug which provides with an alternative to the reference drug in the market. The current noninferiority tests for randomly right-censored data are based on the difference between two survival functions. In this article, we proposed two noninferiority tests based on the difference between two restricted mean lifetimes. One is constructed according to the differences between the restricted mean lifetimes at some specific time points, the other is based on the maximum of all the possible differences over the specific time points. A simulation study is then conducted to compare the type I error rate and power of the proposed tests. Finally, the application of the proposed methods is illustrated by using a real data. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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