Therapeutic Effect of Infrared Irradiation on the Animal Models of Depression
| Autor: | Jui-Feng Tsai, 蔡瑞峰 |
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| Rok vydání: | 2009 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 97 In this study, two animal models of depression using female mice were applied to evaluate the antidepressant effect of infrared irradiation. This study was divided into three parts: (1) In the winter, 17 female mice were randomly assigned to the infrared-irradiated group (n=9) and the control group (n=8). Mice of the infrared-irradiated group received infrared irradiation 60 minutes daily for 4 weeks. In order to assess the antidepressant effect of infrared irradiation, forced swimming test was performed weekly to compare the despaired behavior in terms of the immobility times in these two groups. (2) In order to explore the seasonality of the antidepressant effect of infrared irradiation, 14 female NMRI mice were randomly assigned to the infrared-irradiated (n=7) and control (n=7) groups in the summer. Mice of the infrared-irradiated group received infrared irradiation 60 minutes daily for 6 weeks. Both forced swimming test and tail suspension test were performed weekly to compare the despaired behavior in terms of the immobility times in these two groups. (3) In order to explore whether the antidepressant effect of infrared irradiation was related to the thermal effect, 44 female NMRI mice were randomly assigned to the infrared-irradiated (n=15), heated (n=14) and control (n=15) groups in the winter. Mice of the infrared-irradiated group received infrared irradiation 60 minutes daily for 6 weeks; mice of the heated group received heat diffusion 60 minutes daily to reach about the same temperature as the infrared-irradiated group. Forced swimming test was planned to perform weekly to compare the despaired behavior in these three groups. However, since some mice of the 3 groups died after the attack of two episodes of cold current, we changed to compare the survival rates of the 3 groups instead of the immobility times. The results showed that: (1) In the winter, the immobility times in the forced swimming test of the infrared-irradiated group showed significant difference when compared with those of the control group at the end of the 4th week (independent student t-test: t15 = 2.873；P = 0.012). (2) In the summer, the immobility times in the forced swimming test and tail suspension test of infrared-irradiated and the control groups did not have significant difference (repeated measures MANOVA：P = 0.648, 0.574, respectively). (3) Log-rank test showed that, when compared with the normal control group, the mice of the infrared-irradiated group had a lower relative risk of mortality while encountering the forced swimming test in cold (RR = 0.34；CI = 0.08 – 0.82；P = 0.013), while the heated group did not (RR = 0.54；CI = 0.21 – 1.09；P = 0.087). In summary, the present study utilizing animal models of depression revealed that: (1) Infrared irradiation has potential anti-depressant effect in the winter. The anti-depressant effect may be due to increased serotonin secretion. (2) Infrared irradiation has no potential anti-depressant effect in the summer. That is, the antidepressant effect of the infrared irradiation has seasonality. (3) The antidepressant effect may be not sorely due to thermal effect. It could be related to increased serotonin. It is worthy initiating clinical trial of the infrared irradiation for depressed patients. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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