Effect of momordica charantia L. extracts formula on blood glucose and chronic inflammation in STZ-induced diabetic rats.
| Autor: | Guo-Hua Yu, 於國華 |
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| Rok vydání: | 2008 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 96 Diabetic complications are the major causes of death in diabetic mellitus (DM). Hyperglycemia-induced oxidative damage and hyperlipidemia are involved in the development of diabetic complications. The hypoglycemic and hypolipidemic effects of single dose Momordica charantia L., evening primrose oil, and chromium yeast have been well-known. The purpose of this study was to investigate the effect of a commercial product (GlucoHealth™), with Momordica charantia L. extract as the major ingredient, on fasting plasma glucose (FPG) and inflammatory markers in STZ-induced diabetic rats. Thirty-two male Wistar rats were randomly assigned into four experimental groups, including normal control (C), diabetic control (D), diabetic rats with regular dose (875 mg/kg B.W.) of GlucoHealth™ (M), and diabetic rats with high dose (1750 mg/kg B.W.) of GlucoHealth™ (H). After 8 weeks of feeding, serum concentration of fasting glucose, Oral glucose tolerance test (OGTT), lipid profile (TG, TC, HDL-C), insulin, C-reactive protein (CRP), von Willebrand factor (vWF), malondialdehyde (MDA) were measured. The results of this study showed that serum concentration of fasting glucose, TG, CRP, vWF, and MDA were decreased significantly (p |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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