Sensing Bio-Hazard Metal Cation and Bio-Materials; Design, Synthesis and Spectroscopy
| Autor: | Mei-Lin Ho, 何美霖 |
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| Rok vydání: | 2008 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 96 Chapter 1. General Introduction of Molecular Recognition. Chapter 2~3. Design and Synthesis of Ir(III)-Azacrown (1) and Iridium (1) Complex: Application as a Highly Sensitive Metal Cation Phosphorescence Sensor. A new metal cation probe 1 bearing a central Ir(III) element and 1-aza-15-crown-5-ether substituted pyridyl pyrazolate as the chelate was synthesized. Remarkable differentiation in spectral properties upon metal cation (e.g. Ca2+) complexation makes complex 1 a highly sensitive phosphorescence probe. Subsequently, we demonstrate the concept of Pb2+ cation sensing using the emissive another Ir(III) complex (1) based on the associated decrease of room temperature phosphorescence upon forming the 1:1 adduct 1-Pb2+. Chapter 4. Diaza-18-crown-6 Appended Dual 7-Hydroxyquinolines; Mercury Ion Recognition in Aqueous Solution. 8,8''-(1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7,16-diyl)bis-(methylene)diquinolin-7-ol (TDBQ) was synthesized and proved to recognize Hg2+ via reducing Hg2+ to Hg+, forming a unique Hg22+/TDBQ complex. Chapter 5. Protic Solvent Catalyzed Excited-state Proton Transfer in Multiple Hydrogen Bonding Systems; Its Application in Urea Recognition toward Aqueous Media. Based on synthesis of 3,4,5,6-tetrahydrobis[6-carboxypyrido[3,2-g]indolo] [2,3-a;3'',2''-j]acridine (TCIA) we convey a generic approach to attain urea recognition via forming a 1:1 TCIA/urea hextuple hydrogen bonded complex in aqueous solution. Highly sensitive signal transduction is achieved via the ratiometric fluorescence for excited-state proton transfer (TCIA) versus non proton transfer (TCIA/urea complex). Chapter 6. 15-Crown-5 Functionalized Au Nanoparticles Synthesized via the Single Molecule Exchange Method; Its Application in 15-Crown-5/K+/15-Crown-5 “Sandwiches” as Linking Mechanisms. The single 15-crown-5 functionalized Au nanoparticles (NPs) were synthesized with the assistance of silica particles. The as prepared Au NPs, providing access to the fundamental analysis, were readily applied in K+ recognition and proved to be free from aggregation. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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