Levels of polybrominated diphenyl ethers (PBDEs) in breast milk and their associated factors in Pingtung area.

Autor: hsiu-lien Lin, 林秀蓮
Rok vydání: 2008
Druh dokumentu: 學位論文 ; thesis
Popis: 96
Polybrominated diphenyl ethers (PBDEs) are used as brominated flame retardants (BFRs) to add them on the surface of electronic and plastic products, textiles, and building materials to prevent fire accident. The heavy use of these chemicals, and the manner in which they are applied, has caused PBDEs to leach from the treated materials and accumulate in animals and humans. The property of high lipophilicity, low volatility and persistence makes PBDEs to have a relatively high potential for bioconcentration and biomagnification in the ecosystems. Human exposure to these chemicals is probably through the ingestion (i.e. diet) and inhalation (i.e. house dust) to induce several adverse health effects including neurotoxicity, reproductive toxicity, developmental toxicity, and cancers. This study was randomly selected healthy pregnant women recruited from Pingtung area in Taiwan from 2007 to 2008. All of the participants were answered a detailed questionnaire and gave us breast milk. Thirty congeners of PBDEs in fifty breast milk samples were analyzed by high resolution gas chromatograph with high resolution mass spectrometry (HRGC/HRMS). The averaged PBDE levels in breast milk, lipid content of breast milk, maternal age, pre-pregnant body mass index (BMI), and maternal age were 3.59±1.70 pg/g lipid(n=46), 3.38±1.01%, 30.3± 4.41 years, 21.6±3.92 kg/m2, and 13.0±1.56 years, respectively. The predominant PBDE congeners were BDE-47, BDE-209, and BDE-153 consisting 30, 16.8, and 15.5%, respectively, of the total PBDEs. Few studies have examined the relationship between PBDEs levels in breast milk and menstrual cycle characteristics. In the present study, women with irregular menstrual cycle until now had significantly higher PBDE concentrations (5.19 ng/g lipid) than those with regular menstrual cycle (3.09 ng/g lipid, p=0.001), particularly for hexaBDEs(irregular / regular:1.24 ng/g lipid /0.957 ng/g lipid, p=0.032), heptaBDEs (irregular / regular:0.278 ng/g lipid /0.118 ng/g lipid, p
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