The effects of rice bran oil and γ- oryzanol on insulin resistance and lipid metabolism in rats with type 2 diabetes mellitus

Autor: Chien Ya-Ma, 馬千雅
Rok vydání: 2007
Druh dokumentu: 學位論文 ; thesis
Popis: 95
BACKGROUND AND METHODS: The prevalence of type 2 diabetes mellitus (T2DM) has dramatically increased in the last few years. Cardiovascular disease (CVD) is a major cause of mortality in patients with diabetes, and dyslipidemia is a major CVD risk factor. Rice bran oil is rich in γ- oryzanol, a compound from the unsaponifiable fraction, and has antioxidant and hypolipidemia properties. Palm oil accounts for 18.6% of the total world vegetable oil production, and is next only to soybean oil in terms of world production. The potential of palm oil to cause hyperlipidemia has been proposed, because it is low in polyunsaturated fat and high in saturated fat, predominantly palmitic acid. The aim of this study was to investigate the effects of rice bran oil and γ -oryzanol on insulin resistance and lipids metabolism in T2DM rats. Rats with streptozotocin/nicotinamide-induced T2DM were divided into control (soybean oil), RBO (rice bran oil), PO (palm oil), POO (palm oil plus γ- oryzanol) groups fed cholesterol-free diets containing 15 g of oil per 100 g diet. RESULT: Of the four groups, the PO group had the highest plasma triglycerides concentration. The LDL-C concentration was higher in the PO group than the control and RBO groups. HDL-C concentration was higher in the RBO and POO groups than PO group. The TC/HDL-C ratio was lower in the RBO and POO groups than the control and PO groups. Hepatic total cholesterol concentration was lower in the RBO group than the control and PO groups, and hepatic triglycerides concentration was higher in the PO group than others group. Fecal neutral sterol and bile acid concentration was higher in the RBO and POO groups than control and PO groups. CONCLUSION: The rice bran oil diet significantly improved insulin resistance and lipid metabolism in rats with type 2 diabetes mellitus. γ- Oryzanol has a lipid lowering effect and can therefore improve hyperlipidemia due to ingestion of palm oil.
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