Comparative Study on Marker Components of Nanoscale and Traditional Chinese Medicine
| Autor: | Fon-Chang Liu, 劉鳳樟 |
|---|---|
| Rok vydání: | 2007 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 95 San-Huang-Shel-Shin-Tang( SHXXT) is a popular traditional Chinese medicine formula from "Jin Kui Yao Lve",incoluding Huang Qin(Scutellaruae Radix), Da Huang (Rhei Rhizoma) and Huang Liean(Coptidis Rhizoma). It usually treatment reselessness, hematemesis and epistaxis,sthenia-heat of triple warmer. This research is establishes nanosizing chinese mediine analysis method, the study on comparative analysis of marker components of baicalin、baicalein、wogonin、berberine、palmatine、chrysophanol of nanoscale and traditional Chinese medicine San-Huang-Shel-Shin-Tang(SHSST) were quantified by HPLC method, taht discussed the nanosizing affect marker components, this study will take the formulation of nanosizing Chinese medicine medication security the appraisal in furure and the government department of health constitute the policy making reference in future. The herbal medicine by way of nanosizing, particle size is 140nm, by calculation the plant of cell membrane and the cell wall break completely, the effective component may dissolve directly. And its surface area became big and make the more advantageous medicine effective component dissolves, however the majority of cell membrane and cell wall at individual tranditional herbal medicine of San-Huang-Shel-Shin-Tang were still complete, the effective component dissolves must according to the diffusion and the osmosis, therefore the rate of dissolution will be decreased. When the herbal medicine by way of nanosizing, as compared with six marker components of wogonin、berberine、palmatine、chrysophanol in methanol extract, the result showed that the nanosizing of SHXXT more than commercial extract, coarse powder and herbal medicine, in high temperature condition and solution is water,the concentration of baicalein in nanosizing of SHXXT and coarse power of SHXXT reduce very rapidly and wogonin at each kind of particle size of SHXXT were be destruction. When solution is water by comparative normal and high temperature condition, the amount of baicalin in nanosizing of SHXXT and coarse powder of SHXXT all increase, but the nanosizing of commercial extract and commercial extract was reducted. By calculation the high temperature of water solution make baicalin destruction. San-Huang-Shel-Shin-Tang were quantified marker components of baicalin、baicalein、wogonin、berberine、palmatine、chrysophanol by HPLC method, the content of baicalin、baicalein、wogonin、berberine、palmatine、chrysophanol is 12.25 ± 0.7、6.72 ± 0.02、1.28 ± 0.02、2.68 ± 0.03、0.46 ± 0.02、0.70 ± 0.03 mg/g. By way of compared IR spectrum and the HPLC chromatographic, the absorption peak and the retention time is not changes, the result demonstrated for nanoscale of herbal m |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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