High Intensity Focused Ultrasound For Thyroid Tumor Thermal Therapy
| Autor: | Wei-You Chen, 陳威佑 |
|---|---|
| Rok vydání: | 2006 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 94 The purpose of this study is to investigate the feasibility of using high intensity focused ultrasound(HIFU) to treat thyroid nodules tissue without overheating surrounding normal tissues or inducing skin burn. A single element transducer (diameter 3.5cm、radius of curvature 5.5cm and frequency 4MHz) was used in simulation and in-vitro experiment study. Various input power、precooling、water temperature、sonication time and cooling interval among sonications were investigated to evaluate the lesion formation and temperature elevation. Furthermore, the intensity and thermal dosage distribution of different parameters ultrasound transducer was studied for the purpose of avoiding skin burn and shortening the lesion length. Results indicate that the input power lower than 10W and heating time longer than 10 seconds can produce a lesion within 1cm, 40 seconds cooling time is sufficient to cool down the temperature in front of the lesion. A diameter 4.375cm and radius of curvature 3.5cm transducer is suitable to produce a short lesion with low skin temperature elevation. The simulation and experiment study confirmed the feasibility of using HIFU to treat thyroid nodules, a target area can be treated safely without overheating the surrounding normal tissues by the input power and heating time suggested by the simulation and the in-vitro experiments. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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