The effects of wild bitter gourd on lipid metabolism
| Autor: | Ya-Ming Tseng, 曾雅旻 |
|---|---|
| Rok vydání: | 2006 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 94 The apolipoprotein E knockout (apoE-/-) mice are hyperlipidemic and a good model to study atherosclerosis. In order to know the effects of wild bitter gourd on lipid metabolism, we conducted two experiments in apoE-/- mice. In experiment 1, 18-wk-old apoE-/- mice were assigned to 6 groups and fed different diets as follows: the high fat (20%, w/w) diet (HF, n = 10), HF with 5%wild bitter ground powder (BGP, n = 10), HF with 1% ethyl acetate extract of bitter gourd (EAE, n = 10), HF with 0.5% clofibrate (CF, n = 5), HF with 0.00123% rosiglitazone (TZD, n = 5) and chow diet (C, n = 5). Serum total cholesterol (TC) and triglyceride (TG) concentrations were measured at the end of wk 4, 9 and 17. After 18 wk of feeding, the mice were sacrified. Liver and blood samples were obtained to determine hepatic TC, TG and serum HDL-C concentrations. Data were analyzed by one-way analysis of variance and the Tukey post hoc. The BGP group had a lower level of serum total cholesterol in week 9 and 17 (25 & 39% reduction, respectively, p |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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