Chemical Constituents and Cytotoxicities from the Root Wood of Michelia compressa
| Autor: | Yung-Wen Chen, 陳揚雯 |
|---|---|
| Rok vydání: | 2006 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 94 The methanolic extract of the root wood of Michelia compressa (Maxim.) Sargent (Magnoliaceae) was partitioned into CHCl3, EtOAc, n-BuOH and H2O soluble layers. The CHCl3 soluble layer showed cytotoxicity against MCF-7, NCI-H460 and SF-268 cancer cell lines. Investigation of the chloroform-soluble fraction by chromatography led to the isolation of twenty-seven compounds, which were identified by spectral evidences, including six sesquiterpenes: costunolide (1), reynosin (2), santamarin (3), parthenolide (4), T-cadinol (5) and arbusculin A (6) seven alkaloids: (-)-N-acetylanonaine (7), (-)-N-acetylnornuciferine (8), (-)-N-formylanonaine (9), (-)-romucosine (10), liriodenine (11), (-)-N-formyldehydroanonaine (12) and artabonatine A (13); four amides: N-trans-feruloyltyramine (14), N-cis-feruloyltyramine (15), N-trans-feruloyl-3-methyldopamine (16) and N-cis-feruloyl-3-methyldopamine (17); five lignans: (+)-5,5''-dimethoxylariciresinol (18), (+)-5-methoxylariciresinol (19), (+)-lariciresinol (20), (±)-syringaresinol (21) and 1,2-bis-(4-hydroxy-3-methoxyphenyl)-1,3-propanediol (22); one benzenoid: syringaldehyde (23); four steroids: mixture of 3β-hydroxystigmast-5-en-7-one (24) and 3β-hydroxystigmasta-5,22-dien-7-one (25), mixture of 6β-hydroxystigmast-4-en-3-one (26) and 6β-hydroxystigmasta-4,22-dien-3-one (27). The structures of these compounds were determined by spectral evidences. Among the isolates, costunolide (1) is the major compound and compounds 5, 6, 10, 12, 13, 16~20, 22~27 were isolated for the first time from Michelia compressa. The costunolide (1) and liriodenine (11) showed cytotoxicity against MCF-7 、NCI-H460 and SF-268 cancer cell lines. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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