Role of zona incerta in absence seizure and facial tremor of the rat with spontaneous spike-wave discharge
| Autor: | Yi-Fang Liao, 廖儀芳 |
|---|---|
| Rok vydání: | 2005 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 93 Generalized absence seizures, which are characterized in electroencephalogram by widespread bilaterally synchronous 3 Hz spike-wave discharge (SWD), occur immobile and are accompanied by facial/whisker twitching (WT). Zona incerta (ZI) has a wide projection to several brain sites and is associated with motor and seizure activity. However, the role of ZI in the generation of SWD and WT remains largely unknown. Several microwire sets were chronically implanted into the bilateral barrel cortices, right-side ZI, and bilateral mystacial pads to record and stimulate the ZI activity during SWD. During SWDs, ZI displayed rhythmical activity that time-locked to SWD spikes in all episodes. The durations of ZI rhythmic activity and WT primarily appeared at the initial phase of SWDs with different considerable proportions. Oscillation frequency and spike magnitude of SWDs increased as the ZI or whisker displayed rhythmic activity. Oscillation frequency of SWDs was significantly decreased after lidocaine injection into the mystacial pad, and other aspects of previous observations before and after lidocaine injection were similar. Moreover, obvious evoked responses elicited by ZI microstimulation revealed in the ipsilateral cortex and contralateral vibrissa and neck muscle. In particular, high-frequency (800 Hz) stimulation of ZI significantly ceased SWD and WT, and middle-frequency (200 Hz) stimulation of ZI optionally stopped WT rather than SWD. Lesion of ZI and its neighboring area led to significant reduction of 7-12 powers of activities of the ipsilateral cortex and contralateral vibrissa muscle. Based on these results, ZI may play an important role in the control of SWD and WT. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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