THE EFFECT OF HYDROCEPHALUS ON RAT SENSORIMOTOR CORTEX
| Autor: | Chih-Chung Lu, 盧治中 |
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| Rok vydání: | 2005 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 93 The effects of obstructive hydrocephalus on cerebral cortex was studied on rats with kaolin-induced hydrocephalus. The sensorimotor cortex was studied 1 (acute) and 8 weeks (chronic) following kaolin injection. Obstructive hydrocephalus slowed the weight gain of rats significantly. The intracranial pressures of animals increased to close to 3 folds in acute and drop to 1.8 fold of control levels in chronic cases. The thickness of the Cortex of both acute and chronic animals were all significantly reduced, however with no apparent neuronal loss. Reactive changes of astrocytes, but not microglia, were observed in acute cases. The density of the intensively NOS-positive neurons in normal cortex was low and decreased slightly in acute cases but returned to normal level in chronic cortices. Intracellular dye injection revealed that the length of the dendrites, especially the apical dendrites of layer Ⅴ pyramidal neurons of the acute hydrocephalic animals was significantly decreased. The densities of dendritic spines on the layer Ⅴ pyramidal neurons of both acute and chronic animals were significantly decreased. In conclusion, our results show that obstructive hydrocephalus caused a fast onset of the thinning of the sensorimotor cortex and the remodeling of the dendritic arbors of layer V pyramidal neurons and these phenomena persisted in chronic animals. The reduction of the dendritic spines of layer V pyramidal neurons suggest that the input, and consequently output of the sensorimotor cortices of the hydrocephalic animals were compromised. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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