Systemic Inflammation Induce Synergistic Neurotoxicity of the MPTP in the Mice
| Autor: | Meng-Chang Ko, 柯孟昌 |
|---|---|
| Rok vydání: | 2005 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 93 貳、英文摘要 Parkinson’s disease (PD) is a common progressive neurodegenerative disease. Recent results suggest that PD may represent the final outcome of complicated interactions, including exposure to environmental toxins and the occurrence of inflammation in the brain. In vitro test, the combination of rotenone with lipopolysaccharide (LPS) could enhance the neurotoxic effect of rotenone. Our present results showed that mice receiving a co-treatment of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) with LPS reduced the rota-rod activities but strengthened the grasp ability and reduced the survival ratio of dopaminergic neuron in the pars compacta of substantia nigra (SNpc). Furthermore, pretreatment of resveratrol, an antioxidation drug, could reduce the neurotoxic effect of LPS. Using microdialysis and high performance liquid chromatography, we demonstrated that oxidative stress in SNpc was reduced by resveratrol. These results suggest that systemic inflammation may play an important role in selective destruction of nigrostriatal dopaminergic neurons by MPTP and resveratrol could decrease oxidative stress and protect dopaminergic neurons. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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