The Effects of β-Hydroxy-β-Methylbutyrate Supplementation on the Anthropometry and Protein States of the Residents in Long Term Bedridden and Tube Feeding
| Autor: | Lan-Chi HSIEH, 謝藍琪 |
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| Rok vydání: | 2004 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 93 β-hydroxy-β-methylbutyrate（HMB）is one of the dietary supplements that are mainly used to promote muscle hypertrophy. The purpose of this study was to determine whether HMB supplementation could reduce muscle protein breakdown and increase its synthesis in long term bedridden with tube feeding patients. There are two periods of supplementation, the first lasted for 14 days and the second was designed for 28 days. Patients were randomly assigned to an experimental treatment group (2 g HMB per day) or the control group (without HMB). Testing occurred before and at the end of each session of 14-day or 28-day supplementation. Each patient was assessed at anthropometry measurement, blood hematology, and blood as well as urine chemistry. After the first 14-day period, results analyzed via General Linear Model Repeated Measures two way ANOVA revealed no significant difference between the control and HMB supplemented group, regardless of genders (p> 0.05). During the second 28-day, as supplementation time prolonged from 14 days to 28 days, there are some parameters measured with significant differences between the control and HMB group. It indicated that supplementation of HMB improved the nutritional status of anthropometry, decreased the muscle wasting and inflammation. There was no negative or side effect of treatment detected throughout the experimental duration; hence HMB would be considered effective and safe to residents. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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