Studies on Synthesis and Biological Activities of 4-Anilinofuro[2,3-b]quinoline Derivatives
| Autor: | Huan-Chin Lin, 林煥欽 |
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| Rok vydání: | 2005 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 93 This studies have synthesized certain 4-anilinofuro[2,3-b]quinoline derivatives. We evaluated their cytotoxicity in the NCI’s full panel of sixty human cancer cell lines derived from nine cancer cells: leukemia, non-small-cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, prostate cancer, and breast cancer. (3-chloro-7- methoxyfuro[2,3-b]quinolin-4-yl)-(3-methoxyphenyl)amine (15b) (GI50 = 3.89 �嵱), (3-Chloro-7-methoxyfuro[2,3-b]quinolin-4-yl)-(4-methoxy- phenyl)amine (15c) (GI50 = 0.22 �嵱), 1-[4-(3-Chloro-7-methoxyfuro- [2,3-b]quinolin-4-ylamino)phenyl]ethanone (15e) (GI50 = 0.27 �嵱)and 1-[4-(7-Methoxyfuro[2,3-b]quinolin-4-ylamino)phenyl]ethanone (16e) (GI50 = 0.49 �嵱) demonstrated potent proliferative. The substituent on aniline located at para position was more active than the one located at meta position. The replacement of chloride on C(3) with hydrogen decreased antiproliferative activity. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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