Fabrication of nanostructured biodegrdable membrane via an electrospinning process
| Autor: | Yen-Cheng Yang, 楊炎橙 |
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| Rok vydání: | 2004 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 92 The major purpose of this study is to fabricate a nanostructured Biodegradable non-woven membrane using ElectroSpinning technology from biopolymers. In this study, 5-20wt% polylactide or/and polybutylene succinate-co-adipate solution were prepared to produce some kind non-woven membranes. The polymer solution was feed by an infusion pump to a capillary which connect with direct current power supplier. 0.17~5.1ml/min of feeding rate were applied. A positive high-voltage direct current supplier was used to generate a voltage about 0—30 kV as a driving force. The collector was grounded, and the distance between capillary and collector was fixed in 15 cm. Practically, certain conditions such as DC voltage and solution concentration were finely controlled to investigate the physical, chemical and biological properties of the membranes. Besides the obtained membrane evaluated its physico-chemical properties, and polarizing microscope, electron microscope was used to observe its morphology. Upon voltage, the fiber diameter, the membrane strength and the voltage have the inverse ratio also thick has nothing to do with the membrane were found, but strength most reaches as high as 6.43MPa. Upon concentration, solution can not start to splay when the concentration is lower than 7.5%, oversized is unable to splay when the concentration is higher than 20%, and best polymer soultion concentration for electrospinning is 10~12wt%. The membrane pore size almost can be finely control near 10μm, and also the pore size distribution is over 95%. The caliber size and the fiber diameter become the direct ratio relations upon capillary diameter were found next. PLLA and PBSA could evenly mixed were found in final, and that the fiber diameter and morphology of single component could be control were also found simultaneously. In in vitro study, the membrane released lactic acid in to PBS solution after 5 weeks. Totally, the size and structure of bioabsorbable membrane can be controlled finely via a micro adjustment in jet conditions, and different bioabsorbable polymers which more than 2 kind could be uniformly mixed in nano-scale simultaneously; furthermore, future might as the GTR(guided tissue regeneration) or GBR(guided bone regeneration) membrane for periodontal use. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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