Antipsychotic Drugs Block the Increase of Ketamine-Induced Brain Metabolic Activity
| Autor: | yucheun Chen, 陳毓娟 |
|---|---|
| Rok vydání: | 2002 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 90 Subanesthetic dose of ketamine can induce a constellation of behavioral, perceptual, and cognitive changes in healthy subjects that are strikingly similar to positive, negative, and cognitive symptoms of schizophrenia. In addition, ketamine can precipitate and exacerbate symptoms in schizophrenic patients. In this study the 2-Deoxyglucose method were used to study the regional glucose utilization of the rat treated with acute subanesthetic dose of ketamine 35mg/kg and compared by one of the three antipsycotics: haloperidol (0.5mg/kg); clozapine (10mg/kg); quetiapine (5.0mg/kg). Rats were randomly divided into eight treatment groups and administered (i.p) with: (1) saline/saline control (2) saline/ketamine (3) haloperidol/ketamine (4) clozapine/ ketamine (5) quetiapine/ketamine (6) haloperidol/ saline (7) clozapine/ saline (8) quetiapine/ saline. The 2-Deoxyglucose method was performed 5 minutes after ketamine injection. Rats were killed by overdose of i.p. sodium pentobarbital 45 minutes after 2-Deoxyglucose injection and the local cerebral glucose utilization rate (LCGU) were studied. The mechanism of the ketamine psychosis and the efficacy of the antipsychotic drugs will be evaluated according to the studies of the LCGU changes during brain metabolic activation. As compared to the saline/saline group, the LCGUs of the ketamine group show significant increase (Duncan test, p |
| Databáze: | Networked Digital Library of Theses & Dissertations |
| Externí odkaz: |
|