Evaluation of Carbon Monoxide Exposure during Low-Flow Anesthesia and Effects of Endogenous and Exogenous Factors
| Autor: | Chin-Sheng Tang, 唐進勝 |
|---|---|
| Rok vydání: | 2001 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 89 The major sources for intraoperative carbon monoxide (CO) in the breathing circuit were related to patient’s hemoglobin catabolism, smoking and the degradation between absorbent and anesthetics. After institutional approval, we used a direct-measurement instrument to measure real-time CO concentrations in the breathing circuit under different anesthetic conditions for patients who received desflurane or isoflurane. By applying multiple linear regression models, we tried to evaluate the significant factors to predict CO concentrations in the circuit. We identified patient’s smoking status, preoperative smoking and body weight as well as gas flow rate were important factors of affecting peak and time-weighted CO levels. These four factors could predict about 44.1% and 42.7% of peak and mean inspiratory CO concentrations respectively. We found that patient with chronic smoking habit, preoperative smoking and greater body weight could increase CO concentrations, while increase in gas flow rate could decrease CO concentrations. After controlling these four important factors, we found that inspiratory CO concentrations were not significantly associated with the anesthetic type and concentration under low flow anesthesia. Implications: We found that patient’s smoking status, preoperative smoking, body weight and gas flow rate were major factors of affecting peak and mean CO concentrations in low flow anesthesia. Our direct-measurement system is useful for anesthesiologists to monitor patient’s real time exposures to CO during clinical anesthesia continuously. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
| Externí odkaz: |
|