Synthesis and Biological Activity of N-substituted benzyl-6(7 or8)-bromo-2,3,4,9-tetrahydrofuro[2,3-b]quinolin-3,4-dione
| Autor: | Ying-Geh Cheng, 陳瑩潔 |
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| Rok vydání: | 2001 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 89 A series of N-substituted benzyl-6( 7or 8 )-bromo-2, 3, 4, 9-tetra- hydrofuro[2,3-b]quinolin-3,4-diones has been synthesized and assigned by their spectra data. All of these synthetic compounds were evaluated for antiallergic and antiinflammatory activity by inhibition tests of mast cell degranulation, neutrophil degranulation, and neutrophil superoxide formation. Among these 6-substitute compounds, N-p-methylbenzyl-6-bromo- 2,3,4,9- tetrahydrofuro[2,3-b]quinolin-3,4-dione (9)exhibited inhibitory activity on fMLP-induced neutrophil degranulation. Among these 6or7-substitute compounds, N-benzyl-6-bromo-2,3,4,9-tetrahydrofuro[2,3-b]quinolin-3,4-dione (3), N-p-florobenzyl-6-bromo-2,3,4, 9-tetrahydrofuro[2,3-b]quinolin-3,4-dione (6), N-m-methyl benzyl-6-bromo- 2,3,4,9-tetrahydrofuro[2,3-b]quinolin-3,4-dione (8), N-p-methylbenzyl-6- bromo-2,3,4,9-tetrahydrofuro[2,3-b]quino-lin-3,4-dione (9), N-p- chloro- benzyl -6-bromo-2,3,4,9-tetrahydrofuro[2,3-b]quinolin-3,4-dione (12), N-benzyl-7-bromo-2,3,4,9-tetrahydrofuro[2,3-b]quinolin-3,4-dione (15), N-o-florobenzyl-7-bromo-2,3,4,9-tetrahydro- furo[2,3-b]quinolin-3,4-dione (16), N-m-florobenzyl-7-bromo-2,3,4,9-tetrahydrofuro[2,3-b]quinolin-3,4-dione (17) werw the most promising antiarrhythmic agents. However,the second series of compounds 26-38 is still evaluated and its results will be reported later. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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