Immunoglobulin A deficiency in uremia
| Autor: | Mei-Chuan, Kuo, 郭美娟 |
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| Rok vydání: | 2000 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 88 Infection is one of the major causes of mortality and morbidity in uremic patients. Impaired host defense is the important predisposing factor. We experienced two hemodialysis (HD) patients with recurrent skin and respiratory tract infections in 1992 and 1995. Unexpectedly, we found both of them were IgA deficiency (IgAD). Therefore, we conducted the following studies to survey the prevalence and the mechanisms of IgAD in uremic patients. Serum Immunoglobulin (Ig) G/A/M concentrations of 246 HD, 40 continuous ambulatory peritoneal dialysis (CAPD), 56 chronic renal failure (CRF) patients, and 250 normal controls were examined by Nephelometry. Lower serum IgA concentrations were found in HD and CAPD patients in comparison to normal controls and CRF patients ( 225 ±100 mg/dl, 217 ±97 mg/dl vs. 270 ±96 mg/dl, 296 ±137 mg/dl; p |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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