Colocalization of nitric oxide synthase and neurotransmitters within the muscular layer of the guinea pig esophagus
| Autor: | Hwang, C. H., 黃瓊慧 |
|---|---|
| Rok vydání: | 2000 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 88 Previous studies have shown that there are several kinds of neuroche-micals, such as vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY), present in the gastrointestinal tract of rat. The actions of these neurochemicals similar to the action of neurotransmitter, or neuromodulator, or neurotrophic factors. They can modulate the activity of the gastrointes-tinal tract. In the last few years, nitrergic neurons have been shown to be a major population in the enteric nervous system, and they are supposed to be interneurons as well as an inhibitory motor neurons to the circular smooth muscle of the gastrointestinal tract. Nitric oxide (NO), released by these nitrergic neurons, acts as an inhibitory neurotransmitter to the intestinal smooth muscle, also it acts as a neuromodulator to certain autonomic functions. Because the enteric nervous system of the guinea pig has been used as a model system for the analysis of enteric neural circuits, therefore the aims of the present study are to elucidate the presence and distribution of nitrer-gic neurons or nerve fibers within the esophagus of the guinea pig. The co-localization of other neurotransmitters, such as VIP, CGRP, NPY, or others with nitric oxide synthase (NOS) will also be examined with double labelling using immunocytochemistry. The efferent fibers to the esophagus will also be examined. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
| Externí odkaz: |
|