The effects of traditional acupuncture and electroacupuncture on regeneration of severed rat sciatic nerves repaired with silicone rubber chambers
| Autor: | Cheng-Li Hu, 胡正利 |
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| Rok vydání: | 2000 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 88 The gap length is the most important factor in deciding the method of nerve repair. End-to-end anastomosis and fascicular suturing have been successfully used to repair small defects between severed stumps. But it is not always possible to apply these methods to bridge large gaps. To overcome large gaps, nerve grafting and nerve bridge methods have been developed. The autograft is the best option to repair injured nerves because it will not cause severe tissue reaction during the implantation period. Nevertheless, disadvantages of the autograft include the difficulty of acquiring a donor nerve for grafting and the inevitable risks of surgery at another site. To solve these problems, artificial nerve cuffs or guide tubes are regraded as an alternative. It has been showed that electric current and electromagnic fields can promote the regeneration of injured nerves. Also, traditional acupuncture and electroacupuncture exerted on certain acupuncture points have been demonstrated that they have positive effects on injured nerve. Due to the goal of previous studies was mainly to repair small defects between severed stumps, it is not practical for large gaps commonly seen in clinic. In this study, silicone rubber tubes were used to bridge 10-mm gaps in rat sciatic nerves and then traditional acupuncture or electroacupuncture were applied on two acupuncture points, which were near the ends of dissected nerve stumps. Results revealed that there was no statistical difference of success rate of nerve regeneration between traditional acupuncture/or electroacupuncture group and controls which were repaired with silicone rubber tubes only. However, the ratio of blood vessel areas to total nerve areas in the group of traditional acupuncture and the axonal density, the ratio of total axonal areas to endoneurium areas, the total blood vessel numbers, the areas of total blood vessels, the ratio of blood vessel areas to total nerve areas in the group of electroacupuncture were all significantly larger than those of the controls (P |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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