Effect of Air Pollution on Exhaled Nitric Oxide Levels in Schoolchildren
| Autor: | Chun-Fa Hsieh, 謝泉發 |
|---|---|
| Rok vydání: | 1999 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 87 Asthma is a chronic inflammatory disease of the airway. Recently, studies have found that exhaled nitric oxide (eNO) was correlated with airway inflammation. We used eNO measurement and questionnaire to clarify the effect of air pollution on asthma and airway disease in schoolchildren. Our study subjects were third grade students from 石牌國小 in Taipei and 淡水國小 in Tamshui. We recruited 256 students (male: 133, female: 123) from the two schools. Study was performed between October 1998 and Apr 1999. The effect of children''s atopy or airway disease on eNO, and the effect of air pollutants and children''s eNO were analyzed. Finally, We compared the effect of air pollutants on children with or without atopic airway disease. In the study subjects, 10.2% children had physician-diagnosed asthma, 19.1% children had wheezing, 24.6% children had physician-diagnosed allergic rhinitis, and 5.4% children had physician-diagnosed dermatitis. Family factors that influenced eNO: children''s father with higher education, mother with allergic rhinitis, and sibling with allergic rhinitis would increase children''s eNO level. Children''s factors affecting eNO included: physician-diagnosed asthma, wheeze, allergic rhinitis, dermatitis, cough in the past year, and upper airway infection (at the time of examination) would increase children''s eNO level. Air pollution: Ozone concentration, ambient temperature, and particulate matter would decrease eNO level, but ambient nitric oxide concentration would increase eNO level. We also found that eNO level was continually increasing from October 1998 to Mar 1999. And it was decreased from Mar 1999 to Apr 1999. URI, sulfur dioxide, and particulate matter had more pronounced effect on nonatopic students. We also found that atopic students were more sensitive to ambient temperature. We concluded that atopy, airway disease and air pollution were correlated with eNO. The most important factor in air pollution that influenced children''s eNO was ambient temperature. We also found that eNO had a time-dependent trend. In conclusion, ozone concentration, ambient temperature, ambient nitric oxide, URI, and allergic rhinitis were important on eNO level. |
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