The T cell-mediated immune response in Helocobacter pylori infection
| Autor: | Shiu-Ju Yang, 楊秀菊 |
|---|---|
| Rok vydání: | 1999 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 87 Helicobacter pylori are a human pathogen and recent studies strongly suggest that chronic infection with H. pylori is tightly associated with chronic gastritis, peptic ulcer, and gastric carcinoma. However, only a minority of infected people develop signs and symptoms as well as gastric pathology. Thus, both host and microbial factors may lead to different outcomes of infections. The relationship between cagA expression and cytotoxin expression, and the further linkage of expression of these molecules with disease outcome is still far from being completely understood. The complexity of host-Helicobacter relationships with large variations in the severity of disease in infected population suggests that it is dependent on uncharacterized host factors, in particular, the cell-mediated immune response induced in different host. We are trying to establish a mouse model for further study of pathogenesis mechanism of Helicobacter infection. We also investigated the subsets and cytokine pattern of infiltrating lymphocytes within gastric tissues in Helicobacter gastritis patients. We demonstrated that there was increased lymphocyte infiltration within gastric tissues in Helicobacter gastritis and both B and T cell cells increased but with different pattern of tissue distribution. There were more CD4 + T cells than CD8 + T cells in the infiltrating T cells and with significant IFN-production, demonstrated by in situ hybridization study. In mice animal model, we found that BALB/c and C57BL/6 strains of mice had more significant gastric histopathology changes than C3H strain of mice, indicating that genetic background may influence the histopathological reaction after Helicobacter infection. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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