Effect of Losartan on the Sexual Behaviors of Rats
| Autor: | Wang, Chia-Chen, 王嘉珍 |
|---|---|
| Rok vydání: | 1997 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 85 Losartan是一種選擇性作用於type I angiotensin II接受體的非胜踏 類阻斷劑，這種可供口服的藥物，即將在臨床上廣用於高血壓的治療。 許多文獻已指出，治療高血壓藥物易導致病人的性功能異常。因此，本文 想要探討losartan對於老鼠性功能的影響。急性或長期投予大白鼠 losartan後，無論自發性高血壓老鼠 ( spontaneous hypertensive rats ；SHR ) 或正常大白鼠 ( Wistar-Kyoto rats；WKY ) 的陰莖海綿體內壓 ( intracavernous pressure；ICP ) 都沒有顯著的改變。 由此顯示， losartan不會影響老鼠的勃起反應 ( erection )。 此外，藉由離體實驗 ，angiotensin II或losartan皆不會直接影響陰莖海綿體的基礎張力 ( basal tone )。因此，老鼠的陰莖海綿體可能並沒有angiotensin II接受 體的存在。於是，研究長期口服losartan ( 30 mg / kg / day ; 經口灌 服 )，對於老鼠性行為 (sexual behavior ) 可能出現的作用。 每天灌 食losatan後，SHR的血壓會明顯降低；WKY則較不受影響。 連續投予 losartan三個月後，SHR的mount latency也會被延長；普通老鼠 ( WKY ) 則沒有任何的改變。 除此之外，其他的性行為，在SHR或WKY的老鼠都沒 改變。 利用HPLC - ECD測量血中catecholamine濃度後，在losartan灌 食1個月或3個月之SHR的血中epinephrine濃度出現明顯偏低，而 norepinephrine濃度則只在處理3個月的SHR才出現降低的情形。 因此， 長期給予losartan會有抑制交感神經張力的作用。 經由以上的結果， losartan對性功能的影響可明白地看出，進而幫助病人在服用時的參考， 防止副作用的發生。 Losartan is one of the nonpeptide specific antagonists for type I angiotensin II receptor. It is an orally active drug to be used in the treatment of the hypertensive diseases. Many reports have been indicated that antihypertensive drugs may cause sexual dysfunction in patients. The present study carried out to understand the effect of losartan on sexual functions in rats. No changes of the intracavernous pressure ( ICP ) were observed in both spontaneously hypertensive rats ( SHRs ) and Wistar-Kyoto rats ( WKYs ) after acute or chronic treatment with losartan. These results suggest that the losartan did not affect on the erection in rats. In addition, the present study also found that basal tone of the isolated corpora cavernosa was not influenced by angiotensin II or losartan directly. The absence of angiotensin II receptors in the corpora cavernosa of rats can thus be considered. Then, the sexual behavior have been investigated in both SHRsand WKYs after chronic treatment with losartan ( 30 mg/kg/day, p.o. ). After the daily treatment with losartan, like the lowering of blood pressure, the mount latency was apparently increased in SHRs but not in WKYs. Nevertheless, other behavior parameters were not significantly changed in rats both SHRs and WKYs. Plasma catecholamine concentrations were measured by HPLC-ECD. Plasma concentrations of epinephrine was decreased by losartan for 1 month and 3 months in SHRs, while norepinephrine level was lowered in SHRs only after 3 months. It is suggested that the sympathetic tone was inhibited by losartan for chronic administration. The obtained results can clarify the influence of losartan in sexual functions which may help us to prevent the side effect of this compound before widely application in clinics. |
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