Synthesis of tripeptide-2,6-dimethoxyhydroquinone-3- mercaptoacetyl conjugates as potential antitumor agents
| Autor: | Su Jane Tsai, 蔡淑珍 |
|---|---|
| Rok vydání: | 1995 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 83 The purpose of this study is to synthesize modified tripeptides as human collagenase inhibitors, aiming to inhibit tumor metastasis. The ten tripeptides were prepared by coupling protected amino residues by the DCC/HOBt method in solution phase. Boc-Ile-Trp-Gly-NH2(3), Boc-Leu-Trp-Gly-NH2(2), Boc- Leu-Trp-Gly-OMe(5), Boc-Leu-Trp-Gly-OMe(6), Boc-Leu-Leu-Ala -OMe(8), Boc-Leu-Phe-Gly-OMe(10), Boc-Leu-Trp-Gly-NHOH(11), Boc-Ile-Trp-Gly-NHOH(12), Boc-Leu-Leu-Ala-NHOH(13), Boc-Leu- Phe -Gly-NHOH(14) were coupled with 2,6-dimethylhydroquinone-3- mercaptoacetic acid, as potential antitumor agent. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
| Externí odkaz: |
|