Sister chromatid exchange in ethylene glycol monomethyl ether exposed workers

Autor: Liao,Kuo Tung, 廖國棟
Rok vydání: 1995
Druh dokumentu: 學位論文 ; thesis
Popis: 83
Ethylene glycol monomethyl ether (EGME) is a solvent with broad industrial and commercial applications. It may be absorbed through digestion tract, respiratory tract and skin. Methoxyacetic acid (MAA), the toxic metabolite of EGME, has been reported to cause infertility, hematological toxicity, encephalopathy and teratogenesis in animal study. But the genotoxicity of EGME and its metabolite in animal or in vitro is controversial. There is lacking of genotoxicity study in workers occupational exposed to EGME. The objective of this study is to investigate the relationship between EGME exposure and sister chromatid exchange (SCE) frequency. Furthermore, this study evaluates the correlation between air EGME concentration, urine MAA concentration and the SCE frequency. SCEs and high SCE frequency cells were used as genotoxic biomarkers of EGME exposure. 32 workers were recruited from EGME-exposed plant as exposed group. The frequency of SCE in the exposed group was compared with 26 non-exposed workers selected from EGME non-exposed department in the same company. The result indicates that no significant difference in SCE frequency and high SCE frequency cells was found between the exposed and non- exposed group after adjustment for sex, age and smoking habit. There is no difference in SCE frequency between high exposure and low exposure group, stratified by the air EGME or urine MAA concentrations. There is no significant correlation between air EGME, urine MAA concentrations and the SCE frequencies. Follow-up the SCE frequency of anemic workers a half year later, no significant change of the SCE frequency was found. It is concluded that EGME may not be a potent mutagen and/or carcinogen in such concentrations workers currently exposed to.
Databáze: Networked Digital Library of Theses & Dissertations
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