| Autor: |
Chunfang, Qiu, Gelaye, Bizu, Denis, Marie, Tadesse, Mahlet G., Enquobahrie, Daniel A., Ananth, Cande V., Pacora, Percy N., Salazar, Manuel, Sanchez, Sixto E., Williams, Michelle A. |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Universidad Peruana de Ciencias Aplicadas (UPC)Repositorio Académico - UPC. |
| Druh dokumentu: |
Článek |
| ISSN: |
1948-1756 |
| Popis: |
The genetic architecture of placental abruption (PA) remains poorly understood. We examined variations in SNPs of circadian clock-related genes in placenta with PA risk. We also explored placental and maternal genomic contributions to PA risk. Placental genomic DNA samples were isolated from 280 PA cases and 244 controls. Genotyping was performed using the Illumina Cardio-MetaboChip. We examined 116 SNPs in 13 genes known to moderate circadian rhythms. Logistic regression models were fit to estimate odds ratios (ORs). The combined effect of multiple SNPs on PA risk was estimated using a weighted genetic risk score. We examined independent and joint associations of wGRS derived from placental and maternal genomes with PA. Seven SNPs in five genes (ARNTL2, CRY2, DEC1, PER3 and RORA), in the placental genome, were associated with PA risk. Each copy of the minor allele (G) of a SNP in the RORA gene (rs2899663) was associated with a 30% reduced odds of PA (95% CI 0.52-0.95). The odds of PA increased with increasing placental-wGRS (Ptrend |
| Databáze: |
Networked Digital Library of Theses & Dissertations |
| Externí odkaz: |
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