Repeated occupational-level exposure to the pesticide malathion leads to neuronal atrophy in the dorsal root ganglion

Autor: McNeil, Arian K.
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Druh dokumentu: Text
Popis: Environmental exposure to organophosphate (OP) pesticides, such as malathion, is a risk factor for neuropathy and neurodegeneration. Toxic levels of OPs irreversibly inhibit acetylcholinesterase (AchE) activity, leading to acute paralysis and even death as the neurotransmitter acetylcholine accumulates at cholinergic synapses. In addition, there is compelling evidence that repeated low-level “occupational-like” exposure to OPs is associated with somatosensory defects but the cellular mechanisms for this effect are unclear. We show sensory neuron cell size in the dorsal root ganglia is significantly reduced in rats exposed to occupational level malathion. However, co-administration of a reversible AchE inhibitor, galantamine, prevented this effect.
Databáze: Networked Digital Library of Theses & Dissertations