| Popis: |
Over the past decade there has been an alarming increase in prevalence of autoimmune diseases worldwide. They occur as a result of body’s inability to distinguish between self and non-self. Exposure to environmental microbes can play a crucial role in induction of these diseases. While controlled and targeted immune response is essential to eliminate microbial infection, uncontrolled and inappropriate immune response leads to autoimmune disorders. This review focuses on immune response to fungi and how fungal exposure can lead to autoimmune disorders. Despite disturbing health effects associated to fugal exposure, no standardized exposure limits or threshold limit value has been established yet. The nature and ubiquity of fungal materials makes it difficult to study exposure-disease relationships. |
