| Popis: |
Abnormal glucose tolerance is becoming more commonplace in obese children and adolescents. We sought to determine the prevalence of impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and type 2 diabetes (T2DM) in a cohort of 278 obese youth who had undergone oral glucose tolerance testing. We also sought to determine predictors of impaired glucose tolerance. The prevalence of IFG, IGT, and both IFG and IGT were 8.0%, 6.6%, and 1.8%, respectfully. Two individuals had 2-hour glucose concentrations which met diabetes criteria, and one individual had both fasting and 2- hour glucose concentrations which met diabetes criteria. Measures of insulin resistance (log HOMA-IR and log HOMA-β) were strongly associated with IGT. Non-Hispanic white race was found to be associated with isolated IGT and this relationship was strengthened when measures of insulin resistance were added to the model. We conclude abnormalities in glucose metabolism are common in obese youth, although overt diabetes is rare. Oral glucose tolerance testing should be considered in obese, insulin resistant non-Hispanic white youth with normal fasting glucose concentrations. |
