| Popis: |
The release of low acyl gellan gum from a controlled release system was evaluated at 0, 0.5, 1% concentration of tri-calcium phosphate. Release rates of 6.387, 0.345, and 0.679 mg/h of low acyl gellan gum were obtained for the 0, 0.5, and 1% tri-calcium phosphate, respectively. Additionally, rheological properties were obtained for the 0.5% TCP gel and 1% TCP. Moreover, low acyl gellan gum was enzymatically cleaved into two smaller molecular weight products, named midi-GAGR and mini-GAGR. Rheological testing revealed molecular weights of approximately 5,500 Da and 1,300 Da for midi-GAGR and mini-GAGR, respectively. Furthermore, the antioxidant capacities of both products were evaluated using DPPH assay. Midi-GAGR was able to scavenge 23% of free radicals, while mini-GAGR scavenged 13%. The polysaccharide low acyl gellan gum has shown promise to be engineered to fit clinical applications. |
