| Popis: |
Protein tyrosine phosphatases (PTPs) are proteins which are responsible for removing phosphate group on tyrosine. Although the reaction mechanism of dephosphorylation has been well estabilished, the substrate specificity and physiological roles of PTPs still remain undefined. In this work, modified PTP substrates were utilized to investigate their interactions with PTPs. Moreover, PTPs have been shown to be closely related to many disease including diabetes, obesity and cancer. Therefore development of PTP inhibitors for therapeutic purpose is of great significance. In this work, a One-bead-one-compound library was built to screen for potential PTP1B inhibitors. The positive hits were distinct from the negative ones and they have shown sequence consensus. The hits showed decant inhibition on PTP1B and they will be promising inhibitors after further improvement. |
