| Autor: |
Jackson, LaDonya L. |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
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| Druh dokumentu: |
Text |
| Popis: |
The objectives of this thesis research project were to (i) develop an assay sensitive enough to detect dead or dying pancreatic beta cells and to (ii) use this assay to predict which at-risk individuals will go on to develop T1DM. In vitro and in vivo approaches were utilized for its validation. This novel assay differentiated between beta cells and non-beta cells with higher analytical and diagnostic sensitivity than previous approaches. With the novel application of mathematical models the assay was also able to retrospectively predict which at-risk individuals would go on to develop T1DM with high sensitivity and specificity. This assay has the potential to be applied alone or in combination with islet antibodies to identify individuals in the very early stages of T1DM to allow for earlier intervention and perhaps halt beta cell destruction and thus prevent this disease. |
| Databáze: |
Networked Digital Library of Theses & Dissertations |
| Externí odkaz: |
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