| Popis: |
Bone marrow derived precursors are attracted by tumors [20]. Evidence shows that these bone marrow precursor cells can secrete factors that they will either modulate neovasculature or incorporate tissue vascularization [5, 24]. A bone marrow derived leukocyte population is seen in tumor vasculature, which expresses both hematopoietic and endothelial cell markers and was named as Vascular Leukocytes (VLCs) [3]. This population was not seen outside the tumor microenvironment [22]. In mouse ovarian models, experiments were performed, which showed that there was a dramatic decrease in the bone marrow precursors as tumor develops, particularly precursor B-cells and DCs (PBDs). Those leukocytes are believed to be attracted by subgroup of cytokines called chemokines. Experiments were conducted in ovarian tumors to reveal the profile of chemokines and their receptors, which might be responsible for migration of the PBDs. These results indicate that Exodus 2, RANTES and SDF-1 play a major role in migration of PBDs towards the tumor. |
