| Popis: |
Background: Parkinson’s disease (PD) is a progressive neurological disorder that results in bradykinesia, tremor, muscle rigidity, and postural instability. In most individuals, high cadence dynamic cycling promotes improvement in motor function and mobility, but there is a need for individually tailored high cadence cycling programs to maximize the treatment effects and minimize the heterogeneity in individual responses. Purpose: The first aim developed an individualized exercise rehabilitation paradigm for people with PD by manipulating entropy of cadence and monitoring the level of effort. The second aim examined the effects of patient-specific adaptive dynamic cycling on motor function, functional mobility, and quality of life in individuals with PD. Method: A total of 11 participants (diagnosed with idiopathic PD), were randomized into either a patient-specific adaptive dynamic cycling (PSADC) or an active control (AC) group. Dynamic cycling settings were optimized for each individual in the PSADC group while the settings were not changed in the AC group. Both groups completed 12 exercise sessions over 4 weeks. Motor function, mobility, and quality of life were measured at the baseline and after 12 sessions using UPDRS Motor III, Timed Up and Go (TUG), and PDQ-39 questionnaires. Results: Patient-specific adaptive dynamic cycling promoted significant improvements in clinical UPDRS Motor III score (Pre: 43.33, Post: 36.67), Kinesia UPDRS Motor III score (Pre: 25.142, Post: 23.833), and TUG duration (Pre: 12.37s, Post: 9.99s), but did not improve quality of life (Pre:16.19, Post:19.24). Individuals in the non-adaptive dynamic cycling did not significantly improve motor function (Pre: 28.60, Post: 29.60), mobility (Pre: 11.23s, Post: 10.85s), or quality of life (Pre:20.08, Post:21.07). Conclusion: Individually tailored exercise prescriptions led to significant improvements in motor function and functional mobility in people with PD. |
