Silencing and recombination in yeast ribosomal DNA
| Autor: | O'Kelly, Michael J. T |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: | |
| Druh dokumentu: | Diplomová práce |
| Popis: | Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 2008. Includes bibliographical references (p. 129-132). A bioinformatic and laboratory investigation into S. cerevisiae's system for the maintenance and homogenization of rDNA. Eliminating mutations and heterogeneity in rDNA repeats is necessary evolutionarily, but harmful to individual organisms--and has been linked to aging-related pathology. We present a forensic investigation of this process using a new whole-genome shotgun dataset, and interpret the results in light of experimental results showing the dynamics of rDNA silencing and recombination in laboratory strains. by Michael J.T. O'Kelly. Ph.D. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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