Função de PD-1 na apoptose de linfócitos T na leishmaniose visceral canina
| Autor: | Chiku, Vanessa Marim [UNESP] |
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| Jazyk: | portugalština |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | AlephRepositório Institucional da UNESPUniversidade Estadual PaulistaUNESP. |
| Druh dokumentu: | masterThesis |
| Popis: | Made available in DSpace on 2016-09-27T13:39:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-12-04. Added 1 bitstream(s) on 2016-09-27T13:45:08Z : No. of bitstreams: 1 000870645_20170104.pdf: 242400 bytes, checksum: 9d69e8bb5f77471c03c024ed5ca56917 (MD5) Bitstreams deleted on 2017-01-06T13:21:19Z: 000870645_20170104.pdf,. Added 1 bitstream(s) on 2017-01-06T13:22:02Z : No. of bitstreams: 1 000870645.pdf: 525092 bytes, checksum: 20064957cf347be120a7f3cbbb1f7137 (MD5) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Dogs infected with Leishmania infantum showed a reduction in the number of lymphocytes T. PD-1 (Programmed cell death 1) a new member of the B7-CD28 family, it is expressed by cells of the immune system and its binding to PD-L1 (CD274) or PD-L2 (CD273) induces deactivation of T cells or apoptosis. This study aimed to evaluate the PD-1 expression and its ligands as well as their role in T lymphocyte induction of apoptosis, TNF-α and IL-4 secretion, nitric oxide production and parasite load in dogs with visceral leishmaniasis. We observed that in canine visceral leishmaniasis PD-1 and its ligands involved in induction of apoptosis of T lymphocytes, are regulating the nitric oxide production, TNF-α, IL-4, as well as the parasitic load. This study helps to clarify the mechanism of immune response and immunotherapeutic drugs such as blocking monoclonal antibodies that can influence the LVC FAPESP: 2013/066849 |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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