Análise da interação in vitro entre Fonsecaea pedrosoi e macrofagos peritoneais de camundongos C57/BL6 e BALB/c
| Autor: | YAMANO, Suellen Sirleide Pereira |
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| Jazyk: | portugalština |
| Rok vydání: | 2008 |
| Předmět: | |
| Zdroj: | Repositório Institucional da UFPAUniversidade Federal do ParáUFPA. |
| Druh dokumentu: | masterThesis |
| Popis: | Submitted by Edisangela Bastos (edisangela@ufpa.br) on 2013-03-04T18:46:38Z No. of bitstreams: 2 license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) Dissertacao_AnaliseInteracaoVitro.pdf: 11076207 bytes, checksum: d5fc5bd6532bdaceb159c5cb59308b40 (MD5) Approved for entry into archive by Ana Rosa Silva(arosa@ufpa.br) on 2013-03-05T15:37:51Z (GMT) No. of bitstreams: 2 license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) Dissertacao_AnaliseInteracaoVitro.pdf: 11076207 bytes, checksum: d5fc5bd6532bdaceb159c5cb59308b40 (MD5) Made available in DSpace on 2013-03-05T15:37:51Z (GMT). No. of bitstreams: 2 license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) Dissertacao_AnaliseInteracaoVitro.pdf: 11076207 bytes, checksum: d5fc5bd6532bdaceb159c5cb59308b40 (MD5) Previous issue date: 2008 A cromoblastomicose e uma infeccao subcutanea cronica, granulomatosa, causada pela implantacao traumatica de diversas especies de fungos demaceos, sendo Fonsecaea pedrosoi o principal agente etiologico. O Brasil possui a segunda maior prevalencia mundial da doenca, sendo o estado do Para a maior area endemica. Histologicamente, a cromomicose e caracterizada pela presenca de celulas gigantes, onde podem ser observadas celulas escleroticas fagocitadas por macrofagos. O objetivo do presente estudo foi analisar os diferentes aspectos da interacao de macrofagos peritoneais de camundongos BALB/c e C57/BL6 com conidios ou celulas escleroticas de F. pedrosoi, determinando os indices de infeccao, fagocitose e fusao celular. Os resultados mostraram indices de fagocitose e infeccao maiores em conidios do que em celulas escleroticas para BALB/c (p Chromoblastomycosis (CBM) is a chronic, subcutaneous, granulomatous infection caused by traumatic implantation in the skin of several dematiaceous fungi, usually Fonsecaea pedrosoi. Brazil has second highest disease prevalence in the world and Para State is the most endemic area. Histologically, CBM is characterized by the presence of multinucleated giant cells and sclerotic cells can be found engulfed by macrophages. The objective of this study was to analyze the different aspects of interaction between peritoneal macrophages from BALB/c or C57/BL6 mice with F. pedrosoi conidia or sclerotic cells, calculating infection, phagocytosis and cellular fusion rates. The results showed phagocytosis and infection rates with conidia higher than sclerotic cells to BALB/c (p |
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