| Autor: |
Moratz, Chantal, Hayman, J. Russell, Gu, Hua, Kehrl, John H. |
| Předmět: |
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| Zdroj: |
ETSU Faculty Works. |
| Druh dokumentu: |
Text |
| DOI: |
10.1128/MCB.24.13.5767-5775.2004 |
| Popis: |
Normal lymphoid tissue development and function depend upon chemokine-directed cell migration. Since chemokines signal through heterotrimeric G-protein-coupled receptors, RGS proteins, which act as GTPase-activating proteins for Gα subunits, likely fine tune the cellular responses to chemokines. Here we show that Rgs1-/- mice possess B cells that respond excessively and desensitize improperly to the chemokines CXCL12 and CXCL13. Many of the B-cell follicles in the spleens of Rgs1 -/- mice have germinal centers even in the absence of immune stimulation. Furthermore, immunization of these mice leads to exaggerated germinal center formation; partial disruption of the normal architecture of the spleen and Peyer's patches; and abnormal trafficking of immunoglobulin-secreting cells. These results reveal the importance of a regulatory mechanism that limits and desensitizes chemokine receptor signaling. |
| Databáze: |
Networked Digital Library of Theses & Dissertations |
| Externí odkaz: |
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